GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity 53 1Förderprogramme der EU10

1Förderprogramme der EU10

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GPCR Signalling Complexes – Synthesis, Assembly, Trafficking and Specificity 53 1Förderprogramme der EU10Main Question: G protein coupled receptors are involved in highly efficient and specific activation of signalling pathways. How do GPCR signalling complexes get assembled to generate such specificity? In order to answer this question, we need to understand how receptors and their signalling partners are synthesized, folded and quality controlled in order to generate functional proteins. Then, we need to understand how each partner of the signalling